The ViriChipô Virus Detection Platform
The 4x4mm ViriChipTM is functionalized with an ultramicro array of antibodies using BioForce's Nano eNablerTM
The ViriChipTM captures intact viruses. The specificity of the captured particles is determined by the specificity of the antibodies.
After less than two hours of incubation, virus particles are directly detected using an Atomic Force Microscopy-based reader. The detection is non-destructive and very sensitive, and can also provide size and shape information about the captured particles.
Detects actual viruses, not their byproducts
Multiple virus detection in a single test or increased speed for single type deposition
Incubation and detection take 30 minutes to 2 hours
Does not require labels
No sample preparation
Leaves viruses bioactive
Detects viruses directly from blood, serum, water and other raw samples
Detects viruses even from minute concentrations
Portable AFMs are already available and BioForce is working on a portable ViriChipTM Reader
Lynch, M.; Mosher, C.; Huff, J.; Nettikadan, S.; Johnson, J. and E. Henderson: Functional protein nanoarrays for biomarker profiling. Proteomics 4: 1695-1702, 2004.
Nettikadan, S.; Johnson, J.; Vengasandra, S.G.; Muys, J. and E. Henderson: ViriChip: a solid phase assay for detection and identification of viruses by atomic force microscopy. Nanotechnology 15: 383-389, 2004.